College football odds, lines, picks, bets, predictions for Week 5, 2021: Model backing Cincinnati, Florida

Nick Saban is undefeated against his former assistant coaches at Alabama, but Lane Kiffin and the 12th-ranked Ole Miss Rebels could present a significant challenge on the Week 5 college football schedule Saturday in Tuscaloosa. The Crimson Tide have made quick work of three opponents — Miami, Mercer and Southern Mississippi — while the fourth — No. 11 Florida — took them down to the wire in a 31-29 Week 3 win. No. 1 Alabama is a 14.5-point favorite in the Week 5 college football odds at Caesars Sportsbook, and the point total sits at an eye-popping 79.

Whether or not Kiffin puts a scare into his old boss, the Week 5 college football lines and matchups set up a stacked Saturday. Second-ranked Georgia is laying 18.5-points against No. 8 Arkansas, No. 7 Cincinnati is a 2.5-point favorite at No. 9 Notre Dame, No. 3 Oregon is an eight-point favorite against resurgent Stanford and No. 4 Penn State is a 10.5-point favorite against Indiana. Before making any Week 5 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,300 for $100 players on its top-rated college football picks against the spread. After going a sizzling 9-3 in Week 4, It also enters Week 5 of the 2021 season on a 81-61 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 5 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 5 college football predictions

One of the top college football picks the model is recommending for Week 5: The No. 10 Florida Gators go on the road and cover (-8) against Kentucky. The Wildcats are off to an impressive start, going 4-0 straight up with a 3-0 ATS mark against FBS competition. But this is a big step up in competition, and the Gators are trending in a good direction.

They pushed No. 1 Alabama to the wire in a 2-point loss two weeks ago. Then they overcame a slow start to blow past Tennessee and cover as 19-point favorites last week. Kentucky’s offense only musters 20 points in the simulations, helping the Gators pick up the double-digit win that covers the spread in well over 50 points of simulations.

Another one of the college football predictions from the model: Cincinnati (-2.5) picks up the win and cover at Notre Dame. The Bearcats passed their first test against a big-time nonconference foe at Indiana, beating the Hoosiers 38-24. After a bye week, Cincinnati now has its biggest test of the season.

Cincinnati’s defense is poised to give the Irish a hard time on Saturday as the Bearcats are giving up just 298.7 yards per game this season, which ranks 27th in the nation. Cincy’s stout defense should give Notre Dame trouble this week, and the Bearcats’ offense has more going for it than Wisconsin’s, especially after a bye week. SportsLine’s model shows Cincinnati winning and covering the spread in well over 50 percent of simulations, while the point total stays under 50.5 in over 60 percent of the time.

How to make Week 5 college football picks

The model has also made the call on who wins and covers in every other game on the Week 5 college football schedule, and it’s calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,300 in profit over the past five-plus seasons, and find out.