College football odds, lines, bets, predictions for Week 6, 2021: Computer model picks Michigan, Ole Miss

The 2021 Red River Showdown is part of the Week 6 college football schedule as No. 6 Oklahoma and No. 21 Texas meet in Dallas for their annual rivalry matchup on Saturday at noon ET. Oklahoma is favored by three points in the latest Week 6 college football odds heading into this one at Caesars Sportsbook, and is on a three-game winning streak in the series. Both teams shook off some early struggles to look good last week and come into this game eyeing a run at the Big 12 title.

Which side of that rivalry should you back in your Week 6 college football bets? And which other college football lines should you be targeting this weekend? Before making any Week 6 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 6 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 6 college football predictions

One of the top college football picks the model is recommending for Week 6: No. 17 Ole Miss covers as a 6.5-point favorite over No. 13 Arkansas. The visiting Razorbacks are reeling after a thorough defeat at the hands of Georgia. And after facing one of the best defenses in the country, Arkansas will now go up against one of the best offensive units.

While Ole Miss had its own fall back to earth last week against Alabama, the team still has quarterback Matt Corral orchestrating a high-octane offense. SportsLine’s model projects him to have almost 300 yards of total offense against Arkansas in a 34-24 Ole Miss win. Ole Miss covers in almost 60 percent of simulations. The point total, which sits at 66, goes under in almost 70 percent of simulations.

Another one of the college football predictions from the model: No. 9 Michigan covers as a three-point favorite at Nebraska on Saturday night. Michigan’s off to its best start in a few years, but the Huskers have rebounded after their season-opening loss to Illinois. In a primetime environment in Lincoln with Nebraska coach Scott Frost looking for what would easily be his best win on the job, the underdog has all the motivation it needs.

But Michigan is equipped to win a low-scoring battle if it has to, and showed the past two weeks in wins against Rutgers and Wisconsin that it can still pull out a victory if the other team stops its rushing attack. Quarterback Cade McNamara has shown he can be effective in the limited passing opportunities he’s provided, going 17 for 28 for 197 yards and two touchdowns against Wisconsin. In simulations, SportsLine’s model has Michigan winning more than 60 percent of the time. The point total, which sits at 52, goes under in well over 60 percent of simulations.

How to make Week 6 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 6 college football schedule, and it’s calling for a national title contender to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which national title contender goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,400 in profit over the past five-plus seasons, and find out.

Week 6 college football odds (via Caesars)

Here are the college football lines for some of Week 6’s most notable matchups:

Friday, Oct. 8

Cincinnati vs. Temple (+28.5, 53.5)

Charlotte vs. FIU (+3.5, 59)

Arizona State vs. Stanford (+10, 52)

Saturday, Oct. 9

Vanderbilt vs. Florida (-39, 58.5)

Ohio State vs. Maryland (+20.5, 68)

Michigan State vs. Rutgers (+5, 50)

Arkansas vs. Ole Miss (-6, 66)

Oklahoma vs. Texas (+3.5, 63.5)

SMU vs. Navy (+14.5, 57.5)

Wake Forest vs. Syracuse (+6.5, 57.5)

Georgia vs. Auburn (+14.5, 45)

Boise State vs. BYU (-4, 56)

Penn State vs. Iowa (-3, 41.5)

LSU vs. Kentucky (-3.5, 52.5)

Notre Dame vs. Virginia Tech (+1.5, 46.5)

Michigan vs. Nebraska (+3, 52)

Alabama vs. Texas A&M (+17.5, 50.5)

San Diego State vs. New Mexico State (+19, 44.5)