College football odds, lines, bets, predictions for Week 8, 2021: Computer model picks Notre Dame, Indiana

The Week 8 college football schedule brings another extended lineup of action. No. 14 Coastal Carolina and Appalachian State (+3.5) kick the week off on Wednesday evening. There are then four games on Thursday and Friday leading into another full Saturday. The Week 8 college football odds from Caesars Sportsbook list No. 13 Ole Miss at -10.5 against LSU in the 3:30 p.m. ET SEC on CBS matchup on Saturday.

Other Week 8 college football lines for games involving contenders include No. 4 Alabama (-27.5) against Tennessee, No. 2 Cincinnati (-28) against Navy and No. 6 Michigan (-21.5) against Northwestern. Which college football spreads should you be targeting for your bets this week? Before making any Week 8 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 8 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 8 college football predictions

One of the top college football picks the model is recommending for Week 8: No. 13 Notre Dame covers (-7) against USC at 7:30 p.m. ET on Saturday. The Trojans have lost three of their last five games by at least 14 points. Notre Dame, meanwhile, has covered in three of its last four games. 

The simulations show Notre Dame running back Kyren Williams accounting for close to 100 yards from scrimmage as the Irish cover almost 60 percent of the time. This game also reaches the 60-point plateau in the projections, making the over (58) the clear value play. 

Another one of the college football predictions from the model: Indiana (+19) stays within the three-score spread against No. 5 Ohio State in a 7:30 p.m. ET matchup on Saturday. The Hoosiers don’t look great on paper with a 2-4 overall record and a 0-5 mark against the spread when playing FBS competition. But they’re hoping to get star quarterback Michael Penix Jr. (shoulder) back. 

And they’ve kept it competitive against top-10 competition. They lost by just five points to Michigan State last week and kept it within two scores against Cincinnati earlier this season. The model projects this to be a 13-point game as the Hoosiers cover in well over 50 percent of simulations. There’s also plenty of value on the under (60), as that hits more than 60 percent of the time, making for a great parlay opportunity. 

How to make Week 8 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 8 college football schedule, and it’s calling for a top-10 team to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-10 squad goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Week 8 college football odds (via Caesars)

Here are the college football lines for some of Week 8’s most notable matchups:

Wednesday, Oct. 20

Coastal Carolina vs. Appalachian State (+3.5, 59.5)

Thursday, Oct. 21

Louisiana vs. Arkansas State (+17, 66.5)

Tulane vs. SMU (-14, 70)

FAU vs. Charlotte (+5.5, 54.5)

San Jose State vs. UNLV (+4.5, 46.5)

Friday, Oct. 22

MTSU vs. UConn (+15, 54)

Memphis vs. UCF (-2.5, 64.5)

Colorado State vs. Utah State (+3, 55)

Washington vs. Arizona (+15.5, 44.5)

Saturday, Oct. 23

Wake Forest vs. Army (+3, 52)

Michigan vs. Northwestern (+21.5, 50)

Cincinnati vs. Navy (+28, 50.5)

Wake Forest vs. Army (+3, 52)

Penn State vs. Illinois (+23.5, 46.5)

Oklahoma vs. Kansas (+38, 67.5)

Wisconsin vs. Purdue (+3, 38)

Clemson vs. Pittsburgh (-3.5, 47)

Oklahoma State vs. Iowa State (-7, 47)

Ole Miss vs. LSU (+10.5, 76)

Oregon vs. UCLA (-1.5, 58.5)

UTSA vs. Louisiana Tech (+6, 58)

San Diego State vs. Air Force (-4, 41)

Ohio State vs. Indiana (+19, 60)

NC State vs. Miami (FL) (+3.5, 53)

Texas A&M vs. South Carolina (+21, 44.5)

USC vs. Notre Dame (-7, 58)