College football odds, lines, bets, predictions for Week 8, 2021: Computer model backing Notre Dame, Indiana

Several College Football Playoff contenders will look to stay sharp against big underdogs during the Week 8 college football schedule. The Week 8 college football odds from Caesars Sportsbook list No. 2 Cincinnati as a 27.5-point favorite against Navy, while No. 3 Oklahoma is a huge 38.5-point favorite against Kansas. No. 4 Alabama, meanwhile, is laying 25.5 points against Tennessee.

The latest Week 8 college football spreads in the Big Ten show No. 5 Ohio State at -20 against Indiana, No. 6 Michigan at -23.5 against Northwestern and No. 7 Penn State at -23.5 against Illinois. Can those contenders cover the large Week 8 college football lines, or are there some good value opportunities backing the big underdogs? Before making any Week 8 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 8 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 8 college football predictions

One of the top college football picks the model is recommending for Week 8: No. 13 Notre Dame (-7) easily covers at home against USC in a 7:30 p.m. ET kickoff on Saturday. The Trojans have been beaten by multiple scores by Utah, Oregon State and Stanford over the past six weeks despite the fact that they were favored in all those games. They now take on the role of underdog against a talented Notre Dame squad.

Notre Dame has covered in three of its last four games, a span that included double-digit wins against Wisconsin and Purdue. That’s how the model sees this one playing out as Notre Dame picks up the 13-point win, covering the spread almost 60 percent of the time. The over (58), meanwhile, hits in more than 50 percent of simulations.

Another one of the college football predictions from the model: Indiana (+19) stays within the three-score spread against No. 5 Ohio State in a 7:30 p.m. ET matchup on Saturday. Indiana is 0-5 against the spread and just 2-4 overall. But the Hoosiers have played a tough schedule and the data suggests they’re equipped to keep this game within the three-score spread. They’ve lost to a trio of top-10 teams — Penn State, Michigan State and Cincinnati — by an average of just 14.3 points. The losses at home to Cincinnati and Michigan State came by an average of just 9.5 points.

Indiana quarterback Michael Penix Jr.’s status remains up in the air with a shoulder injury. But Ohio State is dealing with a lengthy injury list of its own, and SportsLine’s model projects that Indiana keeps this game within two scores. The Hoosiers cover in over 60 percent of simulations, while the under (60) hits well over 60 percent of the time.

How to make Week 8 college football picks

The model has also made the call on who wins and covers in every other game on the Week 8 college football schedule, and it’s calling for a top-10 team to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-10 squad goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.