College football odds, lines, bets, predictions for Week 10, 2021: Proven model backing Oregon, Clemson

The Week 10 college football odds at Caesars Sportsbook indicate that some of the top College Football Playoff contenders will roll to big victories. Top-ranked Georgia is a massive 38-point favorite against Missouri. Cincinnati is laying 22.5-points against Tulsa, Alabama is -28.5 against LSU and Ohio State is -15 against Nebraska. That’s not the case for Michigan State, however, as the Spartans are just three-point road favorites against Purdue in the latest Week 10 college football spreads.

Which contenders should you trust in your Week 10 college football bets? And which other college football lines around the nation have value? Before making any Week 10 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 10 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 10 college football predictions

One of the top college football picks the model is recommending for Week 10: Oregon (-6.5) rolls to an easy cover at Washington in a Pac-12 North battle at 7:30 p.m. ET on Saturday. Both teams are strong defensively, which is a big factor in the model going under (51) in well over 50 percent of simulations. But the projections give Oregon the clear upper-hand from a spread perspective as the Ducks hit the 30-point plateau, while Washington doesn’t clear 20 points.

Oregon averages 443.1 yards per game, almost 100 more than Washington’s average. The Ducks have the overall talent edge as well with possible No. 1 pick in the 2022 NFL Draft Kayvon Thibodeaux anchoring the defense. Running back Travis Dye and quarterback Anthony Brown are both talented runners as well, and the model is projecting strong numbers for both. The Ducks pick up a double-digit win that covers the spread over 60 percent of the time, making them a smart choice for Week 10 college football bets.

Another one of the college football predictions from the model: Clemson (-3.5) covers at Louisville in an ACC Atlantic clash at 7:30 p.m. ET on Saturday. The Tigers had been one of the worst teams to bet on all season as they failed to cover in their first six opportunities. But they finally got an ATS win by knocking off Florida State 30-20 last week, covering the 9.5-point spread.

With the offense showing some signs of life in that win, the model now is backing the Tigers to win and cover at Louisville, a team that has lost three of its last four and is giving up 27.1 points per game. The Tigers hold the Cardinals under 20 points in the projections. That’s enough for Dabo Swinney’s team to get the win and cover in more than 60 percent of simulations.

How to make Week 10 college football picks

The model has also made the call on who wins and covers in every other game on the Week 10 college football schedule, and it’s calling for a Top 25 team to go down hard in a surprising upset. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 squad gets stunned? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.