College football odds, lines, bets, top predictions for Week 10, 2021: Proven model picks Oregon, Clemson

No. 2 Alabama still has the second-best title odds of any team in the country, but it cannot afford to slip up down the stretch. The Crimson Tide were upset by Texas A&M as 18-point favorites in early October, leaving them with no wiggle room. They will play host to LSU on Saturday night as part of the Week 10 college football schedule. Alabama is a 28.5-point favorite in the latest Week 10 college football odds at Caesars Sportsbook.

Other important SEC games this week include No. 1 Georgia vs. Missouri and No. 13 Texas A&M vs. No. 14 Auburn. The top-ranked Bulldogs are 38-point favorites, while the Aggies are 4.5-point favorites. Is there value on any of those Week 10 college football spreads? Before making any Week 10 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 10 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 10 college football predictions

One of the top college football picks the model is recommending for Week 10: No. 4 Oregon (-7) rolls to an easy cover at Washington in a Pac-12 North battle at 7:30 p.m. ET on Saturday. The Ducks are currently sitting atop the Pac-12 North and have already knocked off Ohio State earlier this season. They lost to Stanford at the beginning of October, though, so they cannot afford another setback. Oregon is coming off a 52-29 thrashing against Colorado last week.

Washington has already lost four games this season, including a 13-7 defeat against FCS Montana in its opening game. The Huskies have recorded consecutive wins over Arizona and Stanford, but this is going to be a step up in competition. SportsLine’s model has the Ducks covering the spread in almost 60 percent of simulations, while the under (51) is cashing nearly 60 percent of the time. 

Another one of the college football predictions from the model: Clemson (-4) covers at Louisville in a 7:30 p.m. ET start on Saturday. The Tigers are in another must-win position if they want to stay alive for the ACC Atlantic Division crown. They took care of business last week, covering the spread on a last-second touchdown in a 30-20 win over Florida State. Clemson will now try to build on that momentum with a trip to Louisville.

The Tigers have covered the spread in four of their last five games against the Cardinals and have won the last six meetings overall. Louisville is in the midst of a disappointing campaign, having dropped three of its last four games. The Cardinals are being held to 19 points in SportsLine’s projected final score, which has Clemson covering the spread in almost 60 percent of simulations. 

How to make Week 10 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 10 college football schedule, and it’s calling for a Top 25 team to go down hard in a surprising upset. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 squad gets stunned? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Week 10 college football odds (via Caesars)

Here are the college football lines for some of Week 10’s most notable matchups:

Friday, Nov. 5

Virginia Tech vs. Boston College (+3, 47)

Utah vs. Stanford (+7, 52)

Saturday, Oct. 30

Army vs. Air Force (-2.5, 37.5)

Georgia vs. Missouri (+38, 59.5)

Wake Forest vs. UNC (-2.5, 75.5)

SMU vs. Memphis (+6.5, 71)

Ohio State vs. Nebraska (+14.5, 63)

Ole Miss vs. Liberty (+10, 68.5)

Tulsa vs. Cincinnati (-23, 54.5)

Penn State vs. Maryland (+11, 55.5)

Navy vs. Notre Dame (-21, 47)

Michigan State vs. Purdue (+3, 52)

Oklahoma State vs. West Virginia (+3, 49)

Baylor vs. TCU (+6.5, 59)

Auburn vs. Texas A&M (-4.5, 50)

Coastal Carolina vs. Georgia Southern (+19, 61.5)

LSU vs. Alabama (-28.5, 65)

Iowa vs. Northwestern (+12, 40)

Fresno State vs. Boise State (+5.5, 58)

Michigan vs. Indiana (+19.5, 51)

Tennessee vs. Kentucky (-3, 58.5)

Houston vs. USF (+13, 54.5)

Oregon vs. Washington (+6.5,  51)

UTSA vs. UTEP (+12.5, 53)

Clemson vs. Louisville (+3.5, 45.5)