The Louisville Cardinals and the Clemson Tigers will face off in an ACC clash at 7:30 p.m. ET on Saturday, Nov. 6 at Cardinal Stadium. The Cardinals are 4-4 overall and 3-1 at home, while Clemson is 5-3 overall and 1-2 on the road. Clemson is a perfect 6-0 all-time against Louisville.
Clemson is favored by 3.5 points in the latest Louisville vs. Clemson odds from Caesars Sportsbook, and the over-under is set at 45.5. Before making any Clemson vs. Louisville picks, you need to see the college football predictions and betting advice from the model at SportsLine.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Louisville vs. Clemson and just revealed its Week 10 college football picks and predictions. You can head to SportsLine now to see the model’s CFB picks. Here are several college football odds and betting lines for Louisville vs. Clemson:
- Louisville vs. Clemson spread: Louisville +3.5
- Louisville vs. Clemson over-under: 46 points
Featured Game | Louisville Cardinals vs. Clemson Tigers
What you need to know about Louisville
It was all tied up 7-7 at halftime, but U of L was not quite the NC State Wolfpack’s equal in the second half when they met last Saturday. Louisville took a hard 28-13 fall against NC State. No one had a standout game offensively for the Cardinals, but WR Jordan Watkins led the way with one touchdown. One of the most thrilling moments of the game was Watkins’ 76-yard TD reception in the first quarter.
Louisville has been balanced and explosive all year offensively, but will be facing a tough test against Clemson’s defense. The Cardinals have had some defensive issues, however, allowing 415.4 yards and 27.1 points per game. Louisville is 4-4 against the spread in 2021.
What you need to know about Clemson
Meanwhile, the Tigers beat the Florida State Seminoles 30-20 on Saturday. Clemson’s RB Will Shipley looked sharp as he rushed for two TDs and 128 yards on 25 carries. This was the first time Shipley has racked up 100+ rushing yards all year.
Clemson has been uncharacteristically mediocre in 2021. The Tigers defense remains dominant, but that have struggled to score points all year. Quarterback D.J. Uiagalelei has thrown more interceptions than touchdowns in 2021, and the offense is scoring only 21.3 points per game. Clemson is 1-7 against the spread in 2021
How to make Louisville vs. Clemson picks
The model has simulated Louisville vs. Clemson 10,000 times and the results are in. We can tell you that the model is leaning over on the point total, and it’s also generated a point-spread pick that is hitting in over 60 percent of simulations. You can only see the model’s Clemson vs. Louisville picks at SportsLine.
So who wins Clemson vs. Louisville? And which side of the spread hits in over 60 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.
