College football odds, lines, bets, predictions for Week 12, 2021: Proven model picks Pittsburgh, Michigan

There isn’t expected to be much movement at the top of the College Football Playoff rankings this week after the top seven teams all took care of business in Week 11. At least one contender will go down during the Week 12 college football schedule, however, since No. 4 Ohio State hosts No. 7 Michigan. The Buckeyes are 19-point favorites in that one, according to the latest Week 12 college football odds from Caesars Sportsbook. Whichever side drops that one will be a two-loss team, likely costing itself a playoff shot. 

Which side of that spread should you jump on? And which other Week 12 college football lines around the nation have the most value? Before making any Week 12 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 12 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 12 college football predictions

One of the top college football picks the model is recommending for Week 12: No. 21 Pittsburgh (-13.5) covers at home against Virginia in a 3:30 p.m. ET ACC matchup. The Cavaliers come into this one struggling, having lost their last two games to BYU and Notre Dame by a combined 42 points. Facing a Virginia defense that ranks 11th in the ACC in scoring (30.5 ppg), this should be a showcase game for Pitt quarterback and Heisman contender Kenny Pickett. 

The simulations show PIckett throwing for almost 350 yards and three touchdowns. The Panthers win this one by 17 in the projections, giving them the cover almost 60 percent of the time. The under (66.5) also hits almost 60 percent of the time, making this a good game to target for college football parlays. 

Another one of the college football predictions from the model: No. 6 Michigan (-14.5) covers the two-score spread at Maryland in a 3:30 p.m. ET Big Ten kickoff. After starting the season 3-0, the wheels have fallen off for the Terrapins. They’ve won just once straight-up since then and they’re 0-6 against the spread during that span. 

The Wolverines remain in the CFB Playoff hunt and they need wins and some style points. They have been covering machines this year as well with an 8-2 ATS mark, so the model likes Jim Harbaugh’s side to cover the spread 60 percent of the time. 

How to make Week 12 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 12 college football schedule, and it’s calling for an upset that will have a big impact on the College Football Playoff chase. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdog do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,500 in profit over the past five-plus seasons, and find out.

Week 12 college football odds (via Caesars)

Here are the college football lines for some of Week 12’s most notable matchups:

Tuesday, Nov. 16

Toledo vs. Ohio (+6, 54)

Western Michigan vs. Eastern Michigan (+5, 68)

Bowling Green vs. Miami (OH) (-15.5, 51)

Wednesday, Nov. 17

Central Michigan vs. Ball State (-2.5, 62)

Northern Illinois vs. Buffalo (+1.5, 63.5)

Thursday, Nov. 18

Louisville vs. Duke (+19.5, 59)

Friday, Nov. 19

Southern Mississippi vs. Louisiana Tech (-16.5, 51.5)

Memphis vs. Houston (-9.5, 60.5)

Arizona vs. Washington State (-15, 52.5)

Air Force vs. Nevada (-2, 52.5)

San Diego State vs. UNLV (+11, 41)

Saturday, Nov. 20

Wake Forest vs. Clemson (-3.5, 55.5.)

Michigan State vs. Ohio State (-19, 66.5)

Iowa State vs. Oklahoma (-4, 59.5)

Notre Dame vs. Georgia Tech (+15.5, 59.5)

SMU vs. Cincinnati (-12, 64.5)

Michigan vs. Maryland (+14.5, 55.5)

Virginia vs. Pittsburgh (-13.5, 64.5)

Alabama vs. Arkansas (+20.5, 56)

Baylor vs. Kansas State (pick’em, 50)

Ole Miss vs. Vanderbilt (+36.5, 64)

Oregon vs. Utah (-3, 58.5)

Oklahoma State vs. Texas Tech (+10.5, 56.5)