The Louisville Cardinals and Duke Blue Devils square off in an ACC clash on Thursday night. Louisville will visit the Blue Devils on Thursday after securing a big-time win over Syracuse last week. The Blue Devils are reeling after suffering four straight blowout losses. Can Duke’s horrendous defense hold off one of the most dynamic signal-callers in the country in Malik Cunningham?
Kickoff at Wallace Wade Stadium is set for 7:30 p.m. ET. The Cardinals are 20-point favorites in the latest Louisville vs. Duke odds from Caesars Sportsbook, while the over-under for total points scored is 60.5. Before making any Duke vs. Louisville picks or college football predictions, you need to see what the SportsLine Projection Model has to say.
The model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 12 of the 2021 season on a 36-23 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Louisville vs. Duke and locked in its picks and predictions. You can visit SportsLine now to see the model’s picks. Here are the college football odds and betting lines for Duke vs. Louisville:
- Louisville vs. Duke spread: Louisville -20
- Louisville vs. Duke over-under: 60.5 points
- Louisville vs. Duke money line: Louisville -1400, Duke +800
- LOU: The total has gone under in four of Louisville’s last five games
- DUKE: The Blue Devils are 4-1 ATS in their previous five home games
Featured Game | Duke Blue Devils vs. Louisville Cardinals
Why Louisville can cover
The Cardinals are 2-2 against the spread on the road in 2021. While they’ve only won two games by at least 20 points, their 41-3 victory against Syracuse last week was their most impressive win of the season. Cunningham powers Louisville’s offense, and Duke’s defense hasn’t been able to stop teams from scoring consistently.
The Blue Devils are giving up 499.9 yards of offense per game to opposing teams. Only Arkansas State has given up more yardage per contest. Cunningham has thrown for 13 touchdowns and rushed for another 16 this season. If he produces at his usual level, the Blue Devils could fall far behind early.
Why Duke can cover
Duke has been a disappointment in 2021 but has held its own on its home turf. The Blue Devils are 3-1 against the spread at Wallace Wade Stadium. They’re also 3-2 straight up as hosts. Home field advantage could help the Blue Devils cover against a team that’s been much more successful in conference play.
The Blue Devils have one of the most consistent running backs in the FBS at their disposal. Mataeo Durant has racked up 1,095 rushing yards and nine rushing scores on 220 carries. He’s tallied more than 100 all-purpose yards in four of his five home appearances. The Blue Devils could avoid a blowout loss if he can move the chains and help Duke run the clock down.
How to make Louisville vs. Duke picks
SportsLine’s model is leaning under on the total, projecting 59 combined points. It also has generated an against-the-spread pick that cashes in over 60 percent of simulations. You can only get the model’s Duke vs. Louisville picks at SportsLine.
So who wins Louisville vs. Duke? And which side of the spread hits over 60 percent of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has crushed its college football picks, and find out.
