College football odds, lines, predictions for Championship Week, 2021: Model picks Oklahoma State, Cincinnati

The College Football Playoff committee will have some tough decisions to make by Tuesday evening after Michigan upset Ohio State and Oklahoma State held off Oklahoma in Week 13. Several matchups on Championship Week, however, will go a long way in setting the final playoff field. The latest college football odds for Championship Week from Caesars Sportsbook list Georgia as a 6.5-point favorite against Alabama (4 p.m. ET, CBS) in the SEC Championship Game. Cincinnati, meanwhile, is -10.5 against Houston in the AAC title matchup.

Those are just a couple of the games during the college football Championship Week schedule that will impact the final rankings. With so much on the line, which college football spreads should you be targeting? Before making any college football picks for Championship Week, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Championship Week college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Championship Week

One of the top college football picks the model is recommending for Championship Week: Cincinnati (-10.5) covers against Houston in the AAC Championship Game at 4 p.m. ET on Saturday. The Bearcats came in at No. 4 in the last playoff rankings and they held serve in Week 13 with a 35-13 win over East Carolina, covering the 15-point spread in that one. Expected to be on the bubble as the committee evaluates its credentials against Power Five teams, Cincinnati needs a big win over a ranked Houston squad.

SportsLine’s computer says the Bearcats get the job done. The model projects a strong defensive effort for the Bearcats, who hold Houston quarterback Clayton Tune under 200 yards of passing. Cincinnati quarterback Desmond Ridder throws for around 230 yards and rushes for 30 more, helping the Bearcats cover in 60 percent of simulations.

Another one of the college football predictions from the model: Oklahoma State, fresh off a massive Bedlam win over rival Oklahoma, continues its roll and knocks off the Baylor Bears in the Big 12 Championship Game at noon ET on Saturday. The Cowboys pushed (-4) against OU in the 37-33 win. It was just the second time all season they didn’t cover as they enter this week with a 9-1-1 ATS record on the season.

Dave Aranda’s Baylor squad has been solid against the spread as well, going 7-4. But Oklahoma State, still very much in the playoff picture, has more on the line this week, and the model is projecting a big win for the Cowboys. They hold Baylor to just 18 points as the Cowboys cover well over 50 percent of the time. That strong defensive effort also helps the under (46.5) hit, making this game a great target for college football parlays. 

How to make Championship Week college football picks 

The model has also made the call on who wins and covers in every other game during the Championship Week college football schedule, and it’s projecting multiple underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdogs do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Championship Week college football odds (via Caesars)

Here are the college football lines for Championship Week:

Friday, Dec. 3

Conference USA: Western Kentucky vs. UTSA (+1.5, 72)

Pac-12: Oregon vs. Utah (-2.5, 60)

Saturday, Dec. 4

MAC: Kent State vs. Northern Illinois (+3, 72.5)

Big 12: Baylor vs. Oklahoma State (-5, 46.5)

Mountain West: Utah State vs. San Diego State (-6, 50.5)

Sun Belt: Appalachian State vs. Louisiana (+3, 52.5)

SEC: Georgia vs. Alabama (+6.5, 50)

AAC: Houston vs. Cincinnati (-10.5, 54)

ACC: Pittsburgh vs. Wake Forest (+3, 72.5)

Big Ten: Michigan vs. Iowa (+10.5, 43.5)

USC vs. California (-2.5, 57.5)