College football odds, lines, predictions for Championship Week, 2021: Model picks Cincinnati, Oklahoma State

There will be four games during the Championship Week college football schedule that have direct implications when it comes to the College Football Playoff field. No. 5 Oklahoma State will get things started when it faces No. 9 Baylor in the Big 12 title game at noon ET on Saturday. The Cowboys are 5.5-point favorites in the latest Championship Week college football odds at Caesars Sportsbook. They were able to keep their playoff hopes alive with a win over Oklahoma last week.

Other meaningful games on Saturday include championship bouts in the SEC, AAC and Big Ten. Cincinnati is a 10.5-point favorite over Houston in a game that could decide the fourth and final playoff spot. Before making any college football picks for Championship Week on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Championship Week 2021 on a 42-28 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Championship Week college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Championship Week

One of the top college football picks the model is recommending for Championship Week: No. 4 Cincinnati (-10.5) covers against No. 21 Houston in the AAC Championship Game at 4 p.m. ET on Saturday. Cincinnati is one win away from possibly securing a spot as the first Group of Five team to ever make the College Football Playoff, but Houston has other ideas.

The Cougars ride a hard-charging offense into this one, but they’ll face a Cincinnati defense that has consistently been one of the best in the country all season. The Bearcats cover in 60 percent of simulations from SportsLine’s model, making them a top pick for Championship Week. The point total, which sits at 53, goes over in over 50 percent of simulations as well.

Another one of the college football predictions from the model: No. 5 Oklahoma State (-5.5), fresh off a massive Bedlam win over rival Oklahoma, continues its roll and knocks off the No. 9 Baylor Bears in the Big 12 Championship Game at noon ET on Saturday. The Cowboys have been one of the best teams to back in college football this season, covering the spread in nine of their 12 games. 

They have won the last two meetings between these teams, including a 24-14 win over Baylor earlier this year. Senior running back Jaylen Warren rushed for 125 yards and two touchdowns in that game, which allowed the Cowboys to control the tempo. Baylor quarterback Gerry Bohanon completed just 13 of 27 passes against Oklahoma State’s defense in the loss and he’s questionable with a hamstring injury. The Cowboys are covering the spread in almost 60 percent of simulations, while the under (46.5) is cashing nearly 60 percent of the time as well. 

How to make Championship Week college football picks 

The model has also made the call on who wins and covers in every other game during the Championship Week college football schedule, and it’s projecting multiple underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which underdogs do you need to jump on now? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Championship Week college football odds (via Caesars)

Here are the college football lines for Championship Week:

Saturday, Dec. 4

MAC: Kent State vs. Northern Illinois (+3, 72.5)

Big 12: Baylor vs. Oklahoma State (-5.5, 46.5)

Mountain West: Utah State vs. San Diego State (-6, 50.5)

Sun Belt: Appalachian State vs. Louisiana (+3, 52.5)

SEC: Georgia vs. Alabama (+6.5, 50)

AAC: Houston vs. Cincinnati (-10.5, 54)

ACC: Pittsburgh vs. Wake Forest (+3, 72.5)

Big Ten: Michigan vs. Iowa (+10.5, 43.5)

USC vs. California (-2.5, 57.5)