Supremacy in the AFC East will be on the line when the New England Patriots host the Buffalo Bills on Sunday. The Patriots (9-5) hold a one-game lead over the Bills (8-6) in the division. A New England win would clinch the division title for the Patriots, who already own a victory over Buffalo. A Bills win would forge a tie atop the division with two games remaining in the regular season. New England is a 2.5-point favorite in the latest NFL odds from Caesars Sportsbook.
The game is one of 16 on a full Week 16 NFL schedule. Other key NFL matchups include the Cardinals hosting the Colts on Saturday and the Bengals and Ravens battling for the lead in the AFC North. Before making any 16 NFL bets or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 16. If you successfully parlay its picks, you’d be looking at a massive payout of 25-1. You can only see the model’s Week 16 NFL picks at SportsLine.
Top Week 16 NFL picks
After simulating every game 10,000 times, the model is high on the Saints to cover as three-point favorites on Monday Night Football against the Miami Dolphins. New Orleans (7-7) enters the week tied with Minnesota for the third and final wild card spot in the NFC, but loses the tiebreaker to the Vikings based on winning percentage in conference games. Miami, also 7-7, enters the week one game behind the three teams that own the wild card berths in the AFC.
The Saints’ defense is riding high after playing its best game of the season. Last week against the reigning Super Bowl champion Buccaneers, New Orleans did not allow a point, made four sacks and forced two turnovers in a 9-0 victory. The shutout was the first time that quarterback Tom Brady had been blanked in 181 career home starts.
How to make Week 16 NFL parlays
The model also jumped on four other matchups where it says the line is way off, including a divisional battle and games between teams fighting for their playoff lives. You can only see the model’s NFL Week 16 best bets and parlay at SportsLine.
What are the model’s top Week 16 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 15 NFL best bets from a model on a 133-96 run on its top-rated picks, and find out.
