Two Heisman Trophy-winning quarterbacks will take the field when Baker Mayfield and the Tampa Bay Buccaneers host Jayden Daniels and the Washington Commanders in Week 1. The Buccaneers are 3.5-point favorites in the Week 1 NFL betting lines from SportsLine consensus. There are also three divisional matchups to choose from when locking in Week 1 NFL picks, but which teams have the most value in the Week 1 NFL odds?
Elsewhere, Jim Harbaugh will lead the Los Angeles Chargers against the Las Vegas Raiders in an AFC West showdown. The Chargers are 3.5-point favorites at home in the NFL Vegas odds, but should you include Los Angeles in your Week 1 NFL predictions? Before you make any Week 1 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.
For Week 1, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 1 NFL schedule here.
Top Week 1 NFL AI picks
After analyzing every game in Week 1, the AI PickBot says the Broncos cover as 5.5-point underdogs against the Seahawks in a game that has earned an A-rated pick. Denver will trot out rookie quarterback Bo Nix when the Broncos take the field on Sunday. The No. 12 overall pick in the 2024 NFL Draft is coming off a storied college career, passing for 4,508 yards, 45 touchdowns and just three interceptions last season at Oregon. He completed eight of nine passes for 80 yards and a touchdown in Denver’s preseason win over Green Bay.
Denver has also had success against the Seahawks over the years. In fact, the Broncos are 13-6 in their past 19 games against the Seahawks. Meanwhile, Seattle lost five of its last eight to finish the season at 9-8 and miss the playoffs, which is a big reason why the model favors taking the points with Denver in Week 1. See its other Week 1 football predictions and football picks at SportsLine.
How to make Week 1 NFL picks
In addition, the AI PickBot has generated eight more A-rated picks for Week 1. You need to see the AI PickBot’s analysis before making any Week 1 NFL bets. You can only see it at SportsLine.
Who wins and covers each Week 1 NFL game, and which A-rated picks should you be targeting? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.
