No. 16 Oklahoma State opened the season with a 44-20 win over South Dakota State, covering the spread as a 13-point favorite. The Cowboys will try to back up that performance when they host Arkansas during the Week 2 college football schedule. They are 7.5-point favorites in the Week 2 college football odds, even though Arkansas is coming off a 70-0 win over Arkansas-Pine Bluff for its biggest win since 1928. Several other SEC opponents have tricky matchups in Week 2, including No. 14 Tennessee (-7.5) against No. 24 NC State in Charlotte.
The biggest game nationally features No. 10 Michigan (+7.5) vs. No. 3 Texas in a noon ET kickoff on Saturday. Michigan is the defending national champion, but Texas has taken more action in early Week 2 college football bets. Before locking in any college football picks for Week 2 of the 2024 season, be sure to see the latest college football predictions from SportsLine’s proven model.
The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks. Anyone who has followed it has seen strong returns.
Now, it has turned its attention to the latest college football odds and Week 2 college football betting lines on the spread, money line, and over/under. Head here to see every pick.
Top college football predictions for Week 2
One of the college football picks the model is high on during Week 2: South Carolina (+10) covers against Kentucky at 3:30 p.m. ET on Saturday. Many bettors are looking to fade the Gamecocks following their narrow win over Old Dominion, but the model has identified value following the early line movement. South Carolina freshman quarterback LaNorris Sellers made his debut last week, completing 10 of 23 passes for 114 yards.
However, it was a fairly conservative gameplan from Shane Beamer, and Sellers flashed his potential with 68 rushing yards and a game-winning touchdown. The Gamecocks also have a reliable running back in Arkansas transfer Raheim Sanders, who rushed for 88 yards and a touchdown against Old Dominion. Kentucky was not able to get a full Week 1 game under its belt due to weather, so the model has South Carolina covering the spread in nearly 60% of simulations. See the rest of its Week 2 college football picks here.
Another prediction: No. 15 Oklahoma (-29) easily covers the huge spread against Houston in a 7:45 p.m. ET kickoff on Saturday. The Sooners are coming off an impressive season opener, as they rolled to a 51-3 win over Temple as 42.5-point favorites. Sophomore quarterback Jackson Arnold threw for 141 yards and four touchdowns before getting to rest down the stretch of that game.
Oklahoma rushed for 220 yards and a touchdown on 36 carries, averaging 6.1 yards per attempt. Meanwhile, Houston’s offense managed just seven points in a 20-point loss to UNLV in Willie Fritz’s first game as head coach. The model does not expect Houston to look any better this week, as Oklahoma is covering the large spread in over 60% of simulations. See picks for every other game in Week 2 here.
How to make college football picks for Week 2
The model has also made the call on who wins and covers in every FBS matchup in Week 2, and it’s calling for multiple underdogs to win outright. You can only get every pick for every game at SportsLine.
So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.
College football odds for Week 2
See full Week 2 college football picks, odds, predictions here
Friday, Sept. 6
Duke at Northwestern (-3, 36.5)
Saturday, Sept. 7
Texas at Michigan (+7.5, 43.5)
Arkansas at Oklahoma State (-7.5, 62.5)
Kansas State at Tulane (+9.5, 49)
South Carolina at Kentucky (-10, 42.5)
Iowa State at Iowa (-2.5, 35.5)
Michigan State at Maryland (-8.5, 44)
Virginia at Wake Forest (-2.5, 54)
South Florida at Alabama (-31, 64)
Baylor at Utah (-14, 53.5)
Western Michigan at Ohio State (-38, 54)
Colorado at Nebraska (-7.5, 57.5)
Houston at Oklahoma (-29, 49)
Tennessee vs. NC State (+7.5, 60.5)
Boise State at Oregon (-19, 61)
Mississippi State at Arizona State (-6.5, 59.5)
Utah State at USC (-28.5, 63)
