College football odds, lines, picks, bets, predictions for Week 4, 2021: Proven computer backing LSU, UCLA

Group of Five powers are up first on the Week 4 college football odds board when Marshall visits Appalachian State on Thursday evening. The Mountaineers are 7.5-point favorites, according to the latest Week 4 college football spreads from Caesars Sportsbook. There are then four FBS games on Friday, followed by another loaded Saturday slate. Other college football lines of note this weekend include No. 18 Wisconsin (-5.5) against Notre Dame, No. 11 Florida (-20) against Tennessee and No. 7 Texas A&M (-6) against No. 16 Arkansas in the SEC on CBS matchup. 

Is there value on any of those Week 4 college football spreads? And which other lines should you target during the Week 4 college football schedule? Before making any Week 4 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 4 college football predictions

One of the top college football picks the model is recommending for Week 4: LSU (-2.5) goes on the road and covers at Mississippi State in a noon ET SEC West showdown on Saturday. The Tigers dropped their opener against UCLA on the road. Since that point, LSU has outscored McNeese State and Central Michigan 83-28.

Mississippi State, meanwhile, lost to underdog Memphis last week. The Bulldogs are just 1-2 against the spread thus far, and SportsLine’s model shows the Bulldogs struggling on defense as LSU scores 34 points and piles up around 450 yards of total offense in the simulations. LSU covers almost 60 percent of the time, and the over (57) clears in well over 50 percent of simulations. 

Another one of the college football predictions from the model: No. 24 UCLA (-6) covers at Stanford in Pac-12 action at 6 p.m. ET on Saturday. The Bruins had a surprising loss against Fresno State as 11-point favorites in Week 3. That has brought this spread down to a touchdown, and SportsLine’s model sees value in a bounce-back spot for Chip Kelly’s squad.

UCLA is 2-1 against the spread this season. Stanford took care of business against USC and Vanderbilt, but fell flat in a 24-7 loss against Kansas State earlier in the season. The model predicts that UCLA will run for almost 200 yards in this matchup, helping the Bruins cover 60 percent of the time. The over (58.5) is also a substantial value as that hits almost 60 percent of the time. 

How to make Week 4 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 4 college football schedule, and it’s calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past five-plus seasons, and find out.

Week 4 college football odds (via Caesars)

Here are the college football lines for some of Week 4’s most notable matchups:

Thursday, Sept. 23

Marshall vs. Appalachian State (-7.5, 57)

Friday, Sept. 24

MTSU vs. Charlotte (-2.5, 56.5)

Wake Forest vs. Virginia (-4, 67)

Liberty vs. Syracuse (+6, 52.5)

Fresno State vs. UNLV (+31.5, 58.5)

Saturday, Sept. 25

Georgia vs. Vanderbilt (+34, 51)

Notre Dame vs. Wisconsin (-5.5, 46.5)

UMass vs. Coastal Carolina (-36, 67)

Rutgers vs. Michigan (-18.5, 51.5)

Clemson vs. NC State (+10, 47)

Iowa State vs. Baylor (+6.5, 47.5)

Colorado State vs. Iowa (-23, 44.5)

Texas A&M vs. Arkansas (+5.5, 48)

Georgia State vs. Auburn (-27, 57)

UCLA vs. Stanford (+6, 58.5)

Nebraska vs. Michigan State (-5, 51.5)

Kansas State vs. Oklahoma State (-6, 45)

North Carolina vs. Georgia Tech (+12, 63)

Akron vs. Ohio State (-49, 67.5)

Alabama vs. Southern Mississippi (+45, 57.5)

Oklahoma vs. West Virginia (+16.5, 59)

USF vs. BYU (-23, 52)

Arizona vs. Oregon (-28, 58)