The Arizona Cardinals will try to start a season 5-0 for the first time since 1974 when they host the San Francisco 49ers on Sunday. The Cardinals (4-0) are the NFL’s last remaining undefeated team after wins over the Titans, Vikings, Jaguars and Rams. The franchise has been 5-0 just four other times (1922, ’23, ’66 and ’74). The 49ers are 2-2 after back-to-back losses to the Packers and Seahawks. Arizona is a 5.5-point favorite in the latest NFL odds from Caesars Sportsbook, while the Over-Under for total points scored is 50. Which team can you trust with your NFL bets and NFL parlays?
Other key NFL matchups include the Chiefs and Bills battling on Sunday Night Football in a rematch of last season’s AFC Championship Game and the 3-1 Chargers hosting the 3-1 Browns. Before making any Week 5 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 5. If you successfully parlay its picks, you would be looking at a massive payout of 20-1. You can only see the model’s Week 5 NFL picks at SportsLine.
Top Week 5 NFL picks
After simulating every NFL game 10,000 times, the model is high on the Cardinals to cover as five-point favorites at home against the 49ers. Last week, the Cardinals handily defeated the previously unbeaten Rams, 37-20. On the same day, the 49ers fell to the Seahawks, 28-21.
Led by quarterback Kyler Murray, the Cardinals have the No. 1 offense in the league. Arizona leads the league in scoring offense (35.0 points per game) and total offense (440.5 yards per game). The Cardinals are third in passing offense (304.0) and passing yards per game). The Cardinals will take on a San Francisco defense that gives up 25.5 points per game, which ranks in the bottom half of the NFL.
How to make Week 5 NFL parlays
The model also jumped on four other matchups where it says the line is off, including a divisional battle and a game between two playoff teams from a season ago. You can only see the model’s NFL Week 5 best bets at SportsLine.
What are the model’s top Week 5 NFL picks? And which other matchups should you target for a 20-1 payout? Visit SportsLine now to see the Week 5 NFL best bets from a model on a 124-82 run on its top-rated picks, and find out.
