College football odds, lines, bets, predictions for Week 8, 2021: Proven simulation picks Notre Dame, Indiana

Clemson’s hopes of winning the ACC will be in serious jeopardy if it does not find a way to beat No. 23 Pittsburgh on Saturday afternoon. The Tigers have already lost one conference game this season, so they do not have any margin for error. Pittsburgh is sitting atop the ACC Coastal division with a 5-1 (2-0 ACC) record. The Panthers are three-point favorites in the latest Week 8 college football odds at Caesars Sportsbook.

Elsewhere in the ACC, No. 16 Wake Forest will try to remain unbeaten when it faces Army in one of the more intriguing games on the Week 8 college football schedule. Should that be one of the games you target with your Week 8 college football bets? And which other college football lines have value? Before making any Week 8 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 8 of the 2021 season on a 22-9 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 8 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 8 college football predictions

One of the top college football picks the model is recommending for Week 8: No. 13 Notre Dame (-7) covers against USC in a 7:30 p.m. ET kickoff in South Bend. The schools took a break from their storied rivalry due to the pandemic in 2020, but they are now set to meet once again. USC has lost its last four games at Notre Dame and is playing under an interim head coach. Notre Dame has only lost one contest this season — a 24-13 setback to then-No. 7 Cincinnati three weeks ago.

The Fighting Irish picked up a 32-29 win over Virginia Tech in their most recent outing. USC has struggled defensively at times this year, allowing an average of 43 points in its three losses. SportsLine’s model has Notre Dame covering in 60 percent of simulations.

Another one of the college football predictions from the model: Indiana (+21) stays within the three-score spread against No. 5 Ohio State in a 7:30 p.m. ET matchup on Saturday. The Buckeyes have been on a tear since losing to Oregon, and have outscored Tulsa, Akron, Rutgers and Maryland by a combined 161 points.

But the Hoosiers, while on the comedown from their 6-2 season a year ago, still sport a defense that is head and shoulders above the other units Ohio State has faced since suffering that lone loss. Indiana might not be a great candidate on the money line to pull off the upset, but could keep things closer than the public — and Vegas — thinks. In simulations from SportsLine’s model, Indiana covers as the underdog over 60 percent of the time.

How to make Week 8 college football picks

The model has also made the call on who wins and covers in every other game on the Week 8 college football schedule, and it’s calling for a top-10 team to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-10 squad goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.