The 49ers were dealt a serious blow two weeks ago when they placed George Kittle on injured reserve, robbing the team of its best playmaker. While there’s no replacing the All-Pro, San Francisco does have several players capable of stepping up as productive NFL DFS picks. Running backs Trey Sermon and Elijah Mitchell have had their moments in their rookie years, while WR Brandon Aiyuk has a first-round pedigree that’s hard to ignore. They are at the top of the rather-shallow NFL DFS player pool for 49ers vs. Colts on Sunday Night Football.
Can Aiyuk overcome the QB shuffle in San Francisco and finally have a breakout performance against Indianapolis? And who should you favor out of Sermon and Mitchell when formulating your NFL DFS strategy? Before submitting your NFL DFS lineups for Sunday Night Football, be sure to check out the NFL DFS advice, player rankings, stacks and top daily Fantasy football picks from SportsLine’s Mike McClure.
McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.
He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.
Now, McClure has turned his attention to Sunday Night Football slate and locked in his top daily Fantasy football picks. You can only see them by heading to SportsLine.
Top NFL DFS picks for Colts vs. 49ers
One of McClure’s top NFL DFS picks for Sunday Night Football is Wentz. The former Eagle didn’t have to do much in last week’s 31-3 beatdown of the Texans, but Wentz was efficient with two touchdown passes on just 11 pass completions. It was also the third straight game he posted a passer rating above 115.
Wentz should keep the hot streak going against a Niners defense that isn’t as vaunted as years past. San Francisco has the second-fewest interceptions in the league, while Wentz has the fewest thrown INTs of any starting quarterback. Sometimes avoiding negative-point plays are as important as accumulating positive-point plays and Week 7 certainly favors Wentz. Thus, you can see why McClure is high on him for Sunday Night Football.
Part of McClure’s optimal NFL DFS strategy also includes rostering 49ers receiver Deebo Samuel. The third-year pro has produced no matter who is under center for the 49ers as he ranks second in the NFL with 109.6 receiving yards per game. Over the last two weeks, Samuel has shown off his versatility with 214 yards and two TDs through the air and another touchdown on the ground.
To say that Samuel is the No. 1 option in San Francisco would be an understatement. He has 548 receiving yards this year, while all of the other 49ers wideouts have combined for just 250 yards. He has an ideal matchup on Sunday night as the Colts have allowed 10 touchdowns to opposing receivers, which is the most in the NFL. Lock him in your NFL DFS lineups and look for a big return against Indianapolis.
How to set NFL DFS lineups for 49ers vs. Colts
McClure is also targeting an undervalued player who is set to explode for huge numbers on Sunday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here.
So who is Mike McClure putting in his optimal NFL DFS lineups for Sunday Night Football? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2M in winnings, and find out.
