College football odds, lines, bets, predictions for Week 10, 2021: Proven model picks Oregon, Clemson

The Week 10 college football schedule kicks off with a total of five MACtion games on Tuesday and Wednesday. There’s one game on Thursday, two on Friday and then another full Saturday slate. The Week 10 college football odds from Caesars Sportsbook list No. 6 Ohio State as a 14.5-point road favorite at Nebraska, while No. 3 Alabama is -28.5 at home against LSU.

Other college football spreads of note include top-ranked Georgia (-38) against Missouri and No. 13 Texas A&M (-4.5) against No. 12 Auburn in the 3:30 p.m. ET SEC on CBS game. Which lines have the most value during this loaded week of college football action?Before making any Week 10 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters Week 10 of the 2021 season on a 28-15 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 10 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 10 college football predictions

One of the top college football picks the model is recommending for Week 10: No. 7 Oregon easily covers as a 6.5-point favorite at Washington in a 7:30 p.m. ET kickoff on Saturday. Neither team has been great against the spread this season as they both enter this matchup 2-5 ATS. But both of Oregon’s covers have come on the road. 

SportsLine’s model sees Oregon’s defense, which gives up 23.3 points per game on average, holding Washington to just 18 points in this matchup. Oregon quarterback Anthony Brown throws for almost 200 yards in the simulations, while the team combines for over 200 yards on the ground. The Ducks cover in over 60 percent of simulations and the under (51) is a good bet as well because it hits almost 60 percent of the time.

Another one of the college football predictions from the model: Clemson (-3.5) covers at Louisville in another 7:30 p.m. ET Saturday start. The Tigers got their first cover of the season last week in a 30-20 win over Florida State. Scoring 30 points in that game should be a huge confidence builder for an offense that had been struggling mightily.

Louisville has lost three out of four straight up and the model projects that the Tigers won’t have a problem covering this small spread on the road. Quarterback D.J. Uiagalelei throws for almost 250 yards in the simulations as the Tigers cover more than 60 percent of the time.

How to make Week 10 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 10 college football schedule, and it’s calling for a Top 25 team to go down hard in a surprising upset. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 squad gets stunned? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,700 in profit over the past five-plus seasons, and find out.

Week 10 college football odds (via Caesars)

Here are the college football lines for some of Week 10’s most notable matchups:

Tuesday, Nov. 2

Ball State vs. Akron (+19.5, 57.5)

Miami (Ohio) vs. Ohio (+7, 52)

Eastern Michigan vs. Toledo (-9, 53)

Wednesday, Nov. 3

Northern Illinois vs. Kent State (-5, 66.5)

Central Michigan vs. Western Michigan (-10, 63)

Thursday, Nov. 4

Georgia State vs. Louisiana (-11, 53)

Friday, Nov. 5

Virginia Tech vs. Boston College (+3, 47)

Utah vs. Stanford (+7, 52)

Saturday, Oct. 30

Army vs. Air Force (-2.5, 37.5)

Georgia vs. Missouri (+38, 59.5)

Wake Forest vs. UNC (-2.5, 75.5)

SMU vs. Memphis (+6.5, 71)

Ohio State vs. Nebraska (+14.5, 63)

Ole Miss vs. Liberty (+10, 68.5)

Tulsa vs. Cincinnati (-23, 54.5)

Penn State vs. Maryland (+11, 55.5)

Navy vs. Notre Dame (-21, 47)

Michigan State vs. Purdue (+3, 52)

Oklahoma State vs. West Virginia (+3, 49)

Baylor vs. TCU (+6.5, 59)

Auburn vs. Texas A&M (-4.5, 50)

Coastal Carolina vs. Georgia Southern (+19, 61.5)

LSU vs. Alabama (-28.5, 65)

Iowa vs. Northwestern (+12, 40)

Fresno State vs. Boise State (+5.5, 58)

Michigan vs. Indiana (+19.5, 51)

Tennessee vs. Kentucky (-3, 58.5)

Houston vs. USF (+13, 54.5)

Oregon vs. Washington (+6.5,  51)

UTSA vs. UTEP (+12.5, 53)

Clemson vs. Louisville (+3.5, 45.5)