It is shaping up to be another wonderful weekend of soccer action across Europe to send us into the final international break of 2021 on a high. From Southampton vs. Aston Villa on Friday night to the Seville derby between Real Betis and Sevilla on Sunday, there is no shortage of watchable games across the continent and talking points. Antonio Conte will return to the Premier League with Tottenham Hotspur and the Manchester derby is always an emotionally charged affair.
Follow our guide and do not miss a thing.
1. Southampton vs. Aston Villa
Date: Friday, Nov. 5 | Time: 4 p.m. ET
TV and live stream: Peacock
Caesars Sportsbook Odds: Saints +105 | Draw +250 | Villa +260
Why watch: Saints host Villa on Friday in what could be Dean Smith’s final game in charge unless he can halt the Brummie giants’ recent slide in form. Four consecutive defeats since a 1-0 win away at Manchester United for the Villans while Ralph Hasenhuttl’s men are unbeaten in three with two wins. The pair are 14th and 15th respectively so the loser will be looking nervously over their shoulder heading into the international break.
2. Manchester United vs. Manchester City
Date: Saturday, Nov. 6 | Time: 8:30 a.m. ET
TV: NBCSN | Live stream: fuboTV (Try for free)
Caesars Sportsbook Odds: United +360 | Draw +290 | City -138
Why watch: The Manchester derby needs no introduction and likely little to no persuasion to tune in. However, United’s Ole Gunnar Solskjaer remains unconvincing as boss while Pep Guardiola’s men are looking to bounce back from a surprise loss to Crystal Palace last time out.
3. Juventus vs. Fiorentina
Date: Saturday, Nov. 6 | Time: 1 p.m. ET
TV and live stream: Paramount+
Caesars Sportsbook Odds: Juve -163 | Draw +300 | Fiorentina +450
Why watch: One of Italy’s most prestigious grudge matches which is neither local nor political and often not even competitive: these two just plain do not like the other and their respective regions. Add in the fact that Viola are looking stronger this year and that Juve are desperate to catch up having been cut adrift in the title race and this one should be a cracker.
4. RB Leipzig vs. Borussia Dortmund
Date: Saturday, Nov. 6 | Time: 1:30 p.m. ET
TV and live stream: ESPN+
Caesars Sportsbook Odds: RBL +105 | Draw +280 | BVB +230
Why watch: Two of the Bundesliga’s top sides meet, and Jesse Marsch’s Leipzig remain in need of points after drawing with PSG in the UEFA Champions league while Dortmund are hoping to close the gap on Bayern Munich and get over back-to-back losses to Ajax in Europe.
5. Everton vs. Spurs
Date: Sunday, Nov. 7 | Time: 10 a.m. ET
TV: NBCSN | Live stream: fuboTV (Try for free)
Caesars Sportsbook Odds: Everton +200 | Draw +230 | Spurs +140
Why watch: While this will not be Conte’s debut with his new team, it will be his first appearance in the Premier League since leaving Chelsea and the Italian returns as a Serie A champion having led Inter Milan to the Scudetto. He will also renew his acquaintance with Rafa Benitez who is now in charge of the Toffees.
6. West Ham United vs. Liverpool
Date: Sunday, Nov. 7 | Time: 12:30 p.m. ET
TV: NBCSN | Live stream: fuboTV (Try for free)
Caesars Sportsbook Odds: WHU +360 | Draw +290 | LFC -138
Why watch: The Hammers are upwardly mobile in the Premier League as they trail their visitors by two points while the Reds have leaders Chelsea in their sights with a three-point gap to make up. David Moyes’ touchline battle with Jurgen Klopp promises to make for interesting viewing.
7. AC Milan vs. Inter Milan
Date: Sunday, Nov. 7 | Time: 3:45 p.m. ET
TV and live stream: Paramount+
Caesars Sportsbook Odds: Milan +200 | Draw +270 | Inter +125
Why watch: The Derby della Madonnina is arguably Italian soccer’s most prestigious local derby and it pits second in Serie A against the reigning champions in third with a seven-point gap between the two. Inter absolutely must win to remain in title contention.
8. Real Betis vs. Sevilla
Date: Sunday, Nov. 7 | Time: 4 p.m. ET
TV and live stream: ESPN+
Caesars Sportsbook Odds: Betis +180 | Draw +225 | Sevilla +160
Why watch: The Seville derby is always a colorful affair and with just three points and two positions between the hosts in fifth and their visitors in third, this promises to be unmissable at Estadio Benito Villamarin.
Honorable mentions
Saturday, Nov. 6
- Bayern Munich vs. Freiburg, 10:30 a.m. (ESPN+)
- Girondins de Bordeaux vs. Paris Saint-Germain, 4 p.m. (beIN Sports — via fuboTV)
- Real Madrid vs. Rayo Vallecano, 4 p.m. (ESPN+)
Sunday, Nov. 7
- SSC Napoli vs. Hellas Verona, 1 p.m. (Paramount+)
- Chicago Red Stars vs. NJ/NY Gotham FC, 3 p.m. (CBS Sports Network)
- Stade Rennais vs. Olympique Lyonnais, 3:45 p.m. (beIN Sports — via fuboTV)
- Washington Spirit vs. North Carolina Courage, 5 p.m. (Paramount+)
